发明授权
US08673313B2 Cell penetrating peptides and its use fused to biomolecules with therapeutic action
有权
细胞穿透肽及其使用与具有治疗作用的生物分子融合
- 专利标题： Cell penetrating peptides and its use fused to biomolecules with therapeutic action
- 专利标题（中）： 细胞穿透肽及其使用与具有治疗作用的生物分子融合
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申请号： US12671335申请日： 2008-07-31
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公开(公告)号： US08673313B2公开(公告)日： 2014-03-18
- 发明人: Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
- 申请人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
- 申请人地址： CU Ciudad de la Habana
- 专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人地址： CU Ciudad de la Habana
- 代理机构： Hoffmann & Baron, LLP
- 优先权： CU2007-0180 20070731
- 国际申请： PCT/CU2008/000006 WO 20080731
- 国际公布： WO2009/021468 WO 20090219
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/02
摘要：
The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
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