发明授权
US08673962B2 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
有权
3-苯基-3-甲氧基吡咯烷衍生物作为皮质儿茶酚胺能神经传递的调节剂
- 专利标题： 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
- 专利标题（中）： 3-苯基-3-甲氧基吡咯烷衍生物作为皮质儿茶酚胺能神经传递的调节剂
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申请号： US13130438申请日： 2009-11-24
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公开(公告)号： US08673962B2公开(公告)日： 2014-03-18
- 发明人: Clas Sonesson , Lars Swanson , Fredrik Pettersson
- 申请人： Clas Sonesson , Lars Swanson , Fredrik Pettersson
- 申请人地址： SE Gothenburg
- 专利权人： Integrative Research Laboratories Sweden AB
- 当前专利权人： Integrative Research Laboratories Sweden AB
- 当前专利权人地址： SE Gothenburg
- 代理机构： Birch Stewart Kolasch & Birch, LLP
- 优先权： DK200801657 20081124
- 国际申请： PCT/EP2009/065676 WO 20091124
- 国际公布： WO2010/058018 WO 20100527
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; C07D207/12
摘要：
The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention and to the use of these compounds for therapeutic applications.
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