发明授权
US08679452B2 Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase
失效
在固定气相中使用纳摩尔浓度的[11C]二氧化碳进行微型化液体表面反应
![Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase](/docs/US/2014-03-25/US08679452B2/abs.jpg.600x600.jpg)
- 专利标题： Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase
- 专利标题（中）： 在固定气相中使用纳摩尔浓度的[11C]二氧化碳进行微型化液体表面反应
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申请号： US12158712申请日： 2006-12-19
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公开(公告)号： US08679452B2公开(公告)日： 2014-03-25
- 发明人: Tor Kihlberg , Bengt Langstrom
- 申请人： Tor Kihlberg , Bengt Langstrom
- 申请人地址： GB Buckinghamshire
- 专利权人： GE Healthcare Limited
- 当前专利权人： GE Healthcare Limited
- 当前专利权人地址： GB Buckinghamshire
- 代理商 Jean K. Testa
- 国际申请： PCT/IB2006/003700 WO 20061219
- 国际公布： WO2007/072182 WO 20070628
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61M36/14
![Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase](/abs-image/US/2014/03/25/US08679452B2/abs.jpg.150x150.jpg)
摘要：
Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals or precursors for radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
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