Invention Grant
US08679539B2 Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process for the preparation thereof
有权
载药聚（烷基 - 氰基丙烯酸酯）纳米颗粒及其制备方法
- Patent Title: Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process for the preparation thereof
- Patent Title (中): 载药聚（烷基 - 氰基丙烯酸酯）纳米颗粒及其制备方法
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Application No.: US11700226Application Date: 2007-01-31
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Publication No.: US08679539B2Publication Date: 2014-03-25
- Inventor: Yu-Der Lee , Chi-Yu Huang , Chih-Ming Chen
- Applicant: Yu-Der Lee , Chi-Yu Huang , Chih-Ming Chen
- Applicant Address: TW Linyuan Township, Kaohsiung County
- Assignee: Tong Shen Enterprise Co., Ltd.
- Current Assignee: Tong Shen Enterprise Co., Ltd.
- Current Assignee Address: TW Linyuan Township, Kaohsiung County
- Agency: Muncy, Geissler, Olds & Lowe, P.C.
- Main IPC: A61K9/14
- IPC: A61K9/14
Abstract:
A process for preparing the drug-loaded cyanoacrylate nanoparticles is described. The cyanoacrylate nanoparticles which effectively deliver biological and therapeutic agents are synthesized by miniemulsion polymerization with surfactant, pluronic F127 or F68. Before initiation of polymerization, active agents with particularly highly hydrophobicity are dissolved in cyanoacrylate monomer. Compared with the drug-loaded polyalkylcyanoacrylate nanoparticles produced by emulsion polymerization, those produced by miniemulsion polymerization possess higher loading and encapsulation efficiencies. While the content of dissolved agents increases, furthermore, the loading and encapsulation efficiencies increase concurrently.
Public/Granted literature
- US20080182776A1 Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process foe the preparation thereof Public/Granted day:2008-07-31
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