Invention Grant
US08680091B2 6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
失效
6-芳基烷基氨基-2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂
![6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/docs/US/2014-03-25/US08680091B2/abs.jpg.600x600.jpg)
- Patent Title: 6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
- Patent Title (中): 6-芳基烷基氨基-2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂
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Application No.: US13156575Application Date: 2011-06-09
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Publication No.: US08680091B2Publication Date: 2014-03-25
- Inventor: Karen Briner , Manuel Javier Cases-Thomas , Marta Adeva Bartolome , Christopher Stanley Galka , Alicia Marcos Llorente , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , John Cunningham O'Toole , Richard Edmund Rathmell , Matthew Robert Reinhard , Selma Sapmaz , Andrew Caerwyn Williams
- Applicant: Karen Briner , Manuel Javier Cases-Thomas , Marta Adeva Bartolome , Christopher Stanley Galka , Alicia Marcos Llorente , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , John Cunningham O'Toole , Richard Edmund Rathmell , Matthew Robert Reinhard , Selma Sapmaz , Andrew Caerwyn Williams
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent R. Craig Tucker
- Priority: EP05380191 20050901
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D223/16 ; C07D401/12 ; C07D403/12 ; C07D409/12 ; C07D417/12
![6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/abs-image/US/2014/03/25/US08680091B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is —NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.
Public/Granted literature
- US20110269745A1 6-ARYLALKYLAMINO-2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS Public/Granted day:2011-11-03
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