Invention Grant
US08680108B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
有权
取代的稠合芳基和杂芳基衍生物作为PI3K抑制剂
- Patent Title: Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
- Patent Title (中): 取代的稠合芳基和杂芳基衍生物作为PI3K抑制剂
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Application No.: US12972155Application Date: 2010-12-17
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Publication No.: US08680108B2Publication Date: 2014-03-25
- Inventor: Yun-Long Li , Andrew P. Combs , Eddy W. Yue , Hui-Yin Li
- Applicant: Yun-Long Li , Andrew P. Combs , Eddy W. Yue , Hui-Yin Li
- Applicant Address: US DE Wilmington
- Assignee: Incyte Corporation
- Current Assignee: Incyte Corporation
- Current Assignee Address: US DE Wilmington
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/52
- IPC: A61K31/52 ; A61P13/12 ; A61P11/06 ; A61P37/08 ; A61P19/02 ; A61P17/06 ; A61P35/02 ; A61P35/00 ; C12N9/99 ; C07D473/00
Abstract:
The present invention provides fused aryl and heteroaryl derivatives of Formula I: wherein X, V, Y, U, W, Z, R1, R2, Cy, and Ar are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
Public/Granted literature
- US20110183985A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS Public/Granted day:2011-07-28
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