Invention Grant
US08685369B2 Technetium- and rhenium-bis (heteroaryl) complexes, and methods of use thereof
有权
锝和铼 - 双（杂芳基）络合物及其使用方法
- Patent Title: Technetium- and rhenium-bis (heteroaryl) complexes, and methods of use thereof
- Patent Title (中): 锝和铼 - 双（杂芳基）络合物及其使用方法
-
Application No.: US10589405Application Date: 2005-02-14
-
Publication No.: US08685369B2Publication Date: 2014-04-01
- Inventor: John Babich , Kevin Maresca , James Kronauge
- Applicant: John Babich , Kevin Maresca , James Kronauge
- Applicant Address: US MA Cambridge
- Assignee: Molecular Insight Pharmaceuticals, Inc.
- Current Assignee: Molecular Insight Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: K&L Gates LLP
- Agent John M. Garvey; Pei Wu
- International Application: PCT/US2005/004407 WO 20050214
- International Announcement: WO2005/079865 WO 20050901
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to imidazolyl and pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the radionuclide complexes are also described. Another aspect of the invention relates to imidazolyl and pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
Public/Granted literature
- US20080025915A1 Technetium-And Rhenium-Bis (Heteroaryl) Complexes, And Methods Of Use Thereof Public/Granted day:2008-01-31
Information query
