发明授权
- 专利标题： Dual drug dosage forms with improved separation of drugs
- 专利标题（中）： 具有改善药物分离的双重药物剂型
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申请号： US13530631申请日： 2012-06-22
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公开(公告)号： US08685450B2公开(公告)日： 2014-04-01
- 发明人: Jong Lim , John N. Shell , Jenny Louie-Helm
- 申请人： Jong Lim , John N. Shell , Jenny Louie-Helm
- 申请人地址： US CA Newark
- 专利权人： Depomed, Inc.
- 当前专利权人： Depomed, Inc.
- 当前专利权人地址： US CA Newark
- 代理机构： McDermott Will & Emery LLP
- 主分类号： A61K9/22
- IPC分类号： A61K9/22 ; A61K9/24
摘要：
Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.
公开/授权文献
- US20120263792A1 DUAL DRUG DOSAGE FORMS WITH IMPROVED SEPARATION OF DRUGS 公开/授权日：2012-10-18