发明授权
- 专利标题： Compounds that inhibit NFκB and BACE1 activity
- 专利标题（中）： 抑制NF＆Kgr B和BACE1活性的化合物
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申请号： US13094504申请日： 2011-04-26
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公开(公告)号： US08685963B2公开(公告)日： 2014-04-01
- 发明人: Donald W. Landry , Shi Xian Deng , Gangli Gong , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
- 申请人： Donald W. Landry , Shi Xian Deng , Gangli Gong , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
- 申请人地址： US NY New York
- 专利权人： The Trustees of Columbia University in the city of New York
- 当前专利权人： The Trustees of Columbia University in the city of New York
- 当前专利权人地址： US NY New York
- 代理机构： Baker Botts, L.L.P.
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A01N43/42 ; A61K31/47 ; C07D215/36
摘要：
The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
公开/授权文献
- US20120064099A1 COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY 公开/授权日：2012-03-15
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