发明授权
US08686002B2 Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
有权
杂环化合物及其作为5-HT 5受体的结合伴侣的用途
- 专利标题: Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
- 专利标题(中): 杂环化合物及其作为5-HT 5受体的结合伴侣的用途
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申请号: US11990822申请日: 2006-08-21
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公开(公告)号: US08686002B2公开(公告)日: 2014-04-01
- 发明人: Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Charles W. Hutchins , Francisco Javier Garcia-Ladona , Wolfgang Wernet
- 申请人: Wilhelm Amberg , Astrid Netz , Andreas Kling , Michael Ochse , Udo Lange , Charles W. Hutchins , Francisco Javier Garcia-Ladona , Alfred Hahn
- 申请人地址: DE Wiesbaden
- 专利权人: AbbVie Deutschland GmbH & Co. KG
- 当前专利权人: AbbVie Deutschland GmbH & Co. KG
- 当前专利权人地址: DE Wiesbaden
- 代理机构: Michael Best & Friedrich LLP
- 代理商 Lisa V. Mueller
- 优先权: DE102005040602 20050821; DE102006005916 20060209
- 国际申请: PCT/EP2006/008222 WO 20060821
- 国际公布: WO2007/022946 WO 20070301
- 主分类号: C07D215/38
- IPC分类号: C07D215/38 ; C07D239/84 ; C07D401/04 ; C07D405/06 ; C07D409/04 ; C07D409/12 ; C07D471/04 ; C07D491/04 ; A61K31/4706 ; A61P25/28
摘要:
The invention relates to compounds of general formula (I), corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof and the prodrugs of said compounds. The invention also relates to the use of said compounds as binding partners for 5-HT5 receptors for treating diseases that are modulated by a 5-HT5 receptor activity, in particular, for treating neurodegenerative and neuropsychiatric disorders as well as signs, symptoms and dysfunctions.