A fracture reduction is mechanically achieved by supporting a body region having the bone fracture on a frame. A first reduction mechanism on the frame is operated to apply to the bone fracture a first predefined force reduction vector that returns the bone fracture to a corrective alignment in a first anatomic orientation, while also mechanically maintaining the corrective alignment in the first anatomic orientation. Independently, a second reduction mechanism on the frame is operated to apply a second predefined force reduction vector that returns the bone fracture to a corrective alignment in a second anatomic orientation different than the first anatomic orientation without altering the corrective alignment in the first anatomic orientation, while mechanically maintaining the corrective alignment in the second anatomic orientation. The fracture reduction is mechanically fixed by mechanically guiding the placement at least one bone fixing device into the reduced bone fracture.