Invention Grant
US08691813B2 Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
有权
吲哚和苯并恶嗪衍生物作为代谢型谷氨酸受体的调节剂
- Patent Title: Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
- Patent Title (中): 吲哚和苯并恶嗪衍生物作为代谢型谷氨酸受体的调节剂
-
Application No.: US13131360Application Date: 2009-11-24
-
Publication No.: US08691813B2Publication Date: 2014-04-08
- Inventor: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James MacDonald
- Applicant: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James MacDonald
- Applicant Address: US NJ Titusville CH Geneva
- Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma SA
- Current Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma SA
- Current Assignee Address: US NJ Titusville CH Geneva
- Agency: Baker & Hostetler LLP
- Priority: EP08170236 20081128
- International Application: PCT/EP2009/008346 WO 20091124
- International Announcement: WO2010/060589 WO 20100603
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/437
Abstract:
The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds and to the use of such compounds and compositions for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
Public/Granted literature
- US20120035167A1 INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Public/Granted day:2012-02-09
Information query
