发明授权
US08691824B2 Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
失效
某些犬尿氨酸-3-单加氧酶抑制剂，药物组合物及其使用方法
- 专利标题： Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
- 专利标题（中）： 某些犬尿氨酸-3-单加氧酶抑制剂，药物组合物及其使用方法
-
申请号： US13056919申请日： 2009-08-03
-
公开(公告)号： US08691824B2公开(公告)日： 2014-04-08
- 发明人: John Wityak , Leticia M. Toledo-Sherman , Celia Dominguez , Stephen Martin Courtney , Christopher John Yarnold , Paula C. De Aguiar Pena , Andreas Scheel , Dirk Winkler
- 申请人： John Wityak , Leticia M. Toledo-Sherman , Celia Dominguez , Stephen Martin Courtney , Christopher John Yarnold , Paula C. De Aguiar Pena , Andreas Scheel , Dirk Winkler
- 申请人地址： US NY New York
- 专利权人： CHDI Foundation, Inc.
- 当前专利权人： CHDI Foundation, Inc.
- 当前专利权人地址： US NY New York
- 国际申请： PCT/US2009/052560 WO 20090803
- 国际公布： WO2010/017132 WO 20100211
- 主分类号： A61K31/497
- IPC分类号： A61K31/497
摘要：
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
公开/授权文献
信息查询
IPC分类:
