发明授权
- 专利标题： Process
- 专利标题（中）： 处理
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申请号： US11721874申请日： 2005-12-15
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公开(公告)号： US08691995B2公开(公告)日： 2014-04-08
- 发明人: Rajendra Narayanrao Kankan , Srinivas Laxminarayan Pathi
- 申请人： Rajendra Narayanrao Kankan , Srinivas Laxminarayan Pathi
- 申请人地址： IN Mumbai
- 专利权人： Cipla Limited
- 当前专利权人： Cipla Limited
- 当前专利权人地址： IN Mumbai
- 代理机构： Conley Rose, P.C.
- 代理商 Rodney B. Carroll
- 优先权： IN1350/MUM/2004 20041216
- 国际申请： PCT/GB2005/004861 WO 20051215
- 国际公布： WO2006/064249 WO 20060622
- 主分类号： C07D401/12
- IPC分类号： C07D401/12
摘要：
A one-pot process for the preparation of pantoprazole sodium by reacting 2-chloro methyl 3,4-dimethoxy pyridine hydrochloride with 2-mercapto-5-difluoromethoxy benzimidazole in an organic solvent system in presence of a phase transfer catalyst and further treating with aqueous sodium hypohalite solution comprising sodium hydroxide to obtain pantoprazole sodium in high yield and purity. The process for conversion of pantoprazole sodium to pantoprazole sodium sesquihydrate and also pantoprazole sodium monohydrate are also disclosed herein.
公开/授权文献
- US20100016605A1 Process 公开/授权日：2010-01-21
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