Tooth cleaning devices. An embodiment of a tooth cleaning device includes: an elongated head sized to fit in an oral cavity. The elongated head having a first surface and a neck extending from the head. A first tooth cleaning element having a plurality of upstanding wiping members extends upward from below the first surface and extends radially outward from a center of the first tooth cleaning element. Each upstanding wiping member has a free outermost edge that extends upwards substantially from the first surface to the top of the wiping member. A plurality of upstanding arcuate shaped second tooth cleaning elements secured to the head and located outboard of the first tooth cleaning element are also provided. In addition, a plurality of upstanding third tooth cleaning elements are secured to the head and border an edge of the first surface. The third tooth cleaning elements have a circular cross-sectional area.