A method and system for on-demand book production is provided in which covers and book content are synchronized at book binding equipment. In one exemplary system and method, a single printer prints a book cover followed by its corresponding book block. The cover and book block are each sequentially staged and synchronized together for binding in the binding equipment. In another method and system for on-demand book production, covers are printed and encoded at a first printer and a book block printing instruction is initiated in response to decoding of the cover in the binding equipment. Printing of the book block is in a separate but integrated printer and the book block is fed to the binding equipment for binding with the book cover. In each instance, synchronized book covers and book blocks are bound in and output from the binding equipment.