发明授权
US08697813B2 Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems
有权
基于染料交联树枝状纳米簇的可逆荧光光电开关，用于生物体系的高对比度成像
- 专利标题： Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems
- 专利标题（中）： 基于染料交联树枝状纳米簇的可逆荧光光电开关，用于生物体系的高对比度成像
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申请号： US13218608申请日： 2011-08-26
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公开(公告)号： US08697813B2公开(公告)日： 2014-04-15
- 发明人: Yoonkyung Kim , Hye-youn Jung , Bong Hyun Chung
- 申请人： Yoonkyung Kim , Hye-youn Jung , Bong Hyun Chung
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Lucas & Mercanti, LLP
- 优先权： KR10-2011-0018123 20110228; KR10-2011-0084771 20110824
- 主分类号： C08F283/04
- IPC分类号： C08F283/04 ; C08G69/48 ; C08G73/10 ; C08L77/00 ; C08L79/08 ; G02B5/23
摘要：
The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.
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