发明授权
- 专利标题: Cyclic amide derivative, and its production and use
- 专利标题(中): 环状酰胺衍生物,其生产和使用
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申请号: US12715930申请日: 2010-03-02
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公开(公告)号: US08697865B2公开(公告)日: 2014-04-15
- 发明人: Keiji Kubo , Yasuhiro Imaeda
- 申请人: Keiji Kubo , Yasuhiro Imaeda
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理机构: Hamre, Schumann, Mueller & Larson P.C.
- 优先权: JP2004-152000 20040521
- 主分类号: C07D239/04
- IPC分类号: C07D239/04 ; A61K31/496
摘要:
The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1 represents —C(O)—, —S(O)— or —S(O)2—, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2 represents a bond or an optionally substituted lower alkylene, Y2 represents —C(O)—, —S(O)—, —S(O)2— or —C(═NR7)—, X3 represents an optionally substituted C1-4 alkylene or an optionally substituted C2-4 alkenylene, Z3 represents —N(R4)—, —O— or a bond, Z1 represents —C(R2) (R2′)—, —N(R2)—, etc., and Z2 represents —C(R3)(R3′)—, —N(R3)—, etc., or a salt thereof.
公开/授权文献
- US20100160629A1 CYCLIC AMIDE DERIVATIVE, AND ITS PRODUCTION AND USE 公开/授权日:2010-06-24
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