发明授权
- 专利标题： Targeting cancer stem cells with DR5 agonists
- 专利标题（中）： 用DR5激动剂靶向癌症干细胞
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申请号： US13634401申请日： 2011-03-18
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公开(公告)号： US08703712B2公开(公告)日： 2014-04-22
- 发明人: Donald J. Buchsbaum , Albert F. Lobuglio , Tong Zhou , Kimberly Foreman
- 申请人： Donald J. Buchsbaum , Albert F. Lobuglio , Tong Zhou , Kimberly Foreman
- 申请人地址： US AL Birmingham
- 专利权人： The UAB Research Foundation
- 当前专利权人： The UAB Research Foundation
- 当前专利权人地址： US AL Birmingham
- 代理机构： Kilpatrick, Townsend & Stockton LLP
- 国际申请： PCT/US2011/029081 WO 20110318
- 国际公布： WO2011/116344 WO 20110922
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61P35/00 ; A61K39/395 ; C12N5/095 ; C07K16/30
摘要：
Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject.
公开/授权文献
- US20130004521A1 TARGETING CANCER STEM CELLS 公开/授权日：2013-01-03
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