发明授权
US08703946B2 Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors
有权
取代的吡唑并[1,5-A]吡嗪化合物作为mGluR5受体的变构调节剂
![Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors](/docs/US/2014-04-22/US08703946B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors
- 专利标题（中）： 取代的吡唑并[1,5-A]吡嗪化合物作为mGluR5受体的变构调节剂
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申请号： US13314117申请日： 2011-12-07
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公开(公告)号： US08703946B2公开(公告)日： 2014-04-22
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Carrie K. Jones , Shaun R. Stauffer , José Manuel Bartolome-Nebreda , Gregor James McDonald , Susana Conde-Ceide , Han Min Tong
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Carrie K. Jones , Shaun R. Stauffer , José Manuel Bartolome-Nebreda , Gregor James McDonald , Susana Conde-Ceide , Han Min Tong
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 代理机构： Ballard Spahr LLP
- 主分类号： C07D471/00
- IPC分类号： C07D471/00
![Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors](/abs-image/US/2014/04/22/US08703946B2/abs.jpg.150x150.jpg)
摘要：
In one aspect, the invention relates to substituted pyrazolo[1,5-a]pyrazine compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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