- 专利标题： Pharmaceutical compositions of entacapone, levodopa and carbidopa with improved bioavailability
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申请号： US12865745申请日： 2009-02-06
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公开(公告)号： US08709485B2公开(公告)日： 2014-04-29
- 发明人: Munish Talwar , Ritesh Kapoor , Manoj Mashalkar , Girish Kumar Jain
- 申请人： Munish Talwar , Ritesh Kapoor , Manoj Mashalkar , Girish Kumar Jain
- 申请人地址： unknown Chikalthana, Aurangabad
- 专利权人： Wockhardt Limited
- 当前专利权人： Wockhardt Limited
- 当前专利权人地址： unknown Chikalthana, Aurangabad
- 代理机构： Bio Intellectual Property Service LLC (Bio IPS)
- 代理商 O. (Sam) Zaghmout
- 优先权： IN262/MUM/2008 20080206; IN263/MUM/2008 20080206
- 国际申请： PCT/IB2009/050486 WO 20090206
- 国际公布： WO2009/098661 WO 20090813
- 主分类号： A61K31/277
- IPC分类号： A61K31/277 ; A61K9/14 ; A61P25/16
摘要：
The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200®. The invention also relates to processes for making such compositions.
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