发明授权
US08710058B2 Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof
有权
3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪-3-基的多晶型形式 吡啶-3-基） - 苄腈盐酸盐及其制备方法
![Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof](/docs/US/2014-04-29/US08710058B2/abs.jpg.600x600.jpg)
- 专利标题： Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof
- 专利标题（中）： 3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪-3-基的多晶型形式 吡啶-3-基） - 苄腈盐酸盐及其制备方法
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申请号： US13143831申请日： 2009-12-04
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公开(公告)号： US08710058B2公开(公告)日： 2014-04-29
- 发明人: Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
- 申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GmbH
- 当前专利权人： MERCK PATENT GmbH
- 当前专利权人地址： DE Darmstadt
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 优先权： EP09000140 20090108
- 国际申请： PCT/EP2009/008684 WO 20091204
- 国际公布： WO2010/078897 WO 20100715
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/501 ; A61P35/00
![Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof](/abs-image/US/2014/04/29/US08710058B2/abs.jpg.150x150.jpg)
摘要：
Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.
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