Invention Grant
- Patent Title: Macrocyclic cysteine protease inhibitors and compositions thereof
- Patent Title (中): 大环半胱氨酸蛋白酶抑制剂及其组合物
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Application No.: US12446053Application Date: 2007-10-18
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Publication No.: US08710178B2Publication Date: 2014-04-29
- Inventor: Andrew David Abell , James Morriss Coxon , Matthew Alan Jones , Stephen Brian McNabb , Axel Thomas Neffe , Steven Geoffrey Aitken , Blair Gibb Stuart , Janna Marie Nikkel , Joanna Kimberley Duncan , Mutita Klanchantra , James David Morton , Roy Bickerstaffe , Lucinda Jane Goodricke Robertson , Hannah Yun Young Lee , Matthew Stewart Muir
- Applicant: Andrew David Abell , James Morriss Coxon , Matthew Alan Jones , Stephen Brian McNabb , Axel Thomas Neffe , Steven Geoffrey Aitken , Blair Gibb Stuart , Janna Marie Nikkel , Joanna Kimberley Duncan , Mutita Klanchantra , James David Morton , Roy Bickerstaffe , Lucinda Jane Goodricke Robertson , Hannah Yun Young Lee , Matthew Stewart Muir
- Applicant Address: NZ Lincoln, Canterbury NZ Christchurch NZ Henderson Auckland
- Assignee: Lincoln University,Canterprise Limited,Douglas Pharmaceuticals Limited
- Current Assignee: Lincoln University,Canterprise Limited,Douglas Pharmaceuticals Limited
- Current Assignee Address: NZ Lincoln, Canterbury NZ Christchurch NZ Henderson Auckland
- Agency: Dann, Dorfman, Herrell and Skillman, P.C.
- Priority: NZ550631 20061018
- International Application: PCT/NZ2007/000311 WO 20071018
- International Announcement: WO2008/048121 WO 20080424
- Main IPC: A61K38/06
- IPC: A61K38/06 ; A61P9/00 ; A61P25/02 ; C07K5/08
Abstract:
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.
Public/Granted literature
- US20110021434A1 Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof Public/Granted day:2011-01-27
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