Invention Grant
- Patent Title: Guanidine compound
- Patent Title (中): 胍化合物
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Application No.: US13755822Application Date: 2013-01-31
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Publication No.: US08716470B2Publication Date: 2014-05-06
- Inventor: Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Hiroyoshi Yamada , Hisashi Mihara , Norio Seki
- Applicant: Astellas Pharma Inc.
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2011-056031 20110315
- Main IPC: C07D417/04
- IPC: C07D417/04 ; A61K31/5377

Abstract:
[Problem]The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases.[Means for Solution]The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that the compound or a salt thereof of the present invention exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. In addition, the present invention relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound or a salt thereof of the present invention, and an excipient.
Public/Granted literature
- US20130143860A1 GUANIDINE COMPOUND Public/Granted day:2013-06-06
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