Invention Grant
US08722684B2 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
有权
1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪作为具有组合的5-羟色胺再摄取的化合物，用于治疗认知障碍的5-HT3和5-HT1A活性
![1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment](/docs/US/2014-05-13/US08722684B2/abs.jpg.600x600.jpg)
- Patent Title: 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
- Patent Title (中): 1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪作为具有组合的5-羟色胺再摄取的化合物，用于治疗认知障碍的5-HT3和5-HT1A活性
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Application No.: US12301061Application Date: 2007-06-15
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Publication No.: US08722684B2Publication Date: 2014-05-13
- Inventor: Benny Bang-Andersen , Andre Faldt , Arne Mork , Heidi Lopez de Diego , Rene Holm , Tine Bryan Stensbol , Nicholas Moore
- Applicant: Benny Bang-Andersen , Andre Faldt , Arne Mork , Heidi Lopez de Diego , Rene Holm , Tine Bryan Stensbol , Nicholas Moore
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: Fish & Richardson P.C.
- Priority: DK200600824 20060616; DK200601223 20060922; DK200601384 20061025; DK200700427 20070320
- International Application: PCT/DK2007/050075 WO 20070615
- International Announcement: WO2007/144005 WO 20071221
- Main IPC: A61K31/495
- IPC: A61K31/495 ; C07D295/096 ; A61K9/16 ; A61K9/20
![1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment](/abs-image/US/2014/05/13/US08722684B2/abs.jpg.150x150.jpg)
Abstract:
1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
Public/Granted literature
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