Various stents and stent-graft systems for treatment of medical conditions are disclosed. In one embodiment, an exemplary stent-graft comprises first and second stents, which each may comprise a series of distal apices disposed distal to a proximal end of the graft, and a series of proximal apices disposed proximally beyond the proximal end of the graft. In one example, the first stent comprises a first uniform segment, and the second stent comprises a second uniform wire segment, where the first uniform segment comprises portions disposed both internal and external to the second uniform wire segment.