发明授权
- 专利标题: Immunopotentiative composition
- 专利标题(中): 免疫组成
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申请号: US12959307申请日: 2010-12-02
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公开(公告)号: US08728474B2公开(公告)日: 2014-05-20
- 发明人: Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
- 申请人: Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
- 申请人地址: JP Osaka JP Kyoto
- 专利权人: Ono Pharmaceutical Co., Ltd.,Tasuku Honjo
- 当前专利权人: Ono Pharmaceutical Co., Ltd.,Tasuku Honjo
- 当前专利权人地址: JP Osaka JP Kyoto
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2002-194491 20020703; JP2003-029846 20030206
- 主分类号: A61K39/395
- IPC分类号: A61K39/395
摘要:
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
公开/授权文献
- US20110081341A1 IMMUNOPOTENTIATIVE COMPOSITION 公开/授权日:2011-04-07