发明授权
US08728488B2 Methods of inducing an immune response in a host by administering flavivirus immunogens comprising extracellular viral particles composed of the premembrane (prM) and envelope (E) antigens
有权
通过施用包含由前膜（prM）和包膜（E）抗原构成的细胞外病毒颗粒的黄病毒免疫原在宿主中诱导免疫应答的方法
- 专利标题： Methods of inducing an immune response in a host by administering flavivirus immunogens comprising extracellular viral particles composed of the premembrane (prM) and envelope (E) antigens
- 专利标题（中）： 通过施用包含由前膜（prM）和包膜（E）抗原构成的细胞外病毒颗粒的黄病毒免疫原在宿主中诱导免疫应答的方法
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申请号： US13338529申请日： 2011-12-28
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公开(公告)号： US08728488B2公开(公告)日： 2014-05-20
- 发明人: Gwong-Jen J. Chang
- 申请人： Gwong-Jen J. Chang
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N7/04
摘要：
The invention encompasses nucleic acid molecules containing transcription units which encode the flavivirus M and E protein antigens. The flaviviruses include Japanese encephalitis virus, dengue, yellow fever virus and St. Louis encephalitis virus. The nucleic acids function to provide the M and E protein antigens when the nucleic acid resides in an appropriate host cell, especially when the host cell is the cell of a subject. The invention also encompasses a vaccine whose active agent is the nucleic acid. The invention further encompasses the cultured host cells when they contain within them nucleic acid molecules containing the transcription units. The invention in addition encompasses a method of immunizing a subject against flavivirus infection by administering to the subject an effective amount of a vaccine containing a nucleic acid molecule containing the transcription unit of the invention.
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