发明授权
- 专利标题： Selection and characterization of novel plant-derived recombinant human interferons with broad spectrum activity
- 专利标题（中）： 具有广谱活性的新型植物来源的重组人类干扰素的选择和表征
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申请号： US13478330申请日： 2012-05-23
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公开(公告)号： US08729236B2公开(公告)日： 2014-05-20
- 发明人: Hal S. Padgett , Fakhrieh S. Vojdani , Andrew A. Vaewhongs
- 申请人： Hal S. Padgett , Fakhrieh S. Vojdani , Andrew A. Vaewhongs
- 代理商 Wayne P. Fitzmaurice
- 主分类号： C07K14/52
- IPC分类号： C07K14/52
摘要：
Methods to derive novel hybrid type 1 interferons that are broadly active against highly pathogenic viruses of biodefense significance are described. Libraries of hybrid interferon genes were produced using gene shuffling, the proteins were expressed, and screened for activity against viruses of interest. Sequences of several broadly active hybrid interferons are described.