发明授权
US08735557B2 Activated sialic acid derivatives for protein derivatisation and conjugation
有权
用于蛋白质衍生化和共轭的活化唾液酸衍生物
- 专利标题: Activated sialic acid derivatives for protein derivatisation and conjugation
- 专利标题(中): 用于蛋白质衍生化和共轭的活化唾液酸衍生物
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申请号: US13544882申请日: 2012-07-09
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公开(公告)号: US08735557B2公开(公告)日: 2014-05-27
- 发明人: Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
- 申请人: Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
- 申请人地址: GB London
- 专利权人: Lipoxen Technologies Limited
- 当前专利权人: Lipoxen Technologies Limited
- 当前专利权人地址: GB London
- 代理机构: One3 IP Management PC
- 代理商 Peter D Weinstein; Dean G. Stathakis
- 优先权: EP05251017 20050223; WOPCT/GB2005/003160 20050812
- 主分类号: C08B37/00
- IPC分类号: C08B37/00 ; C07H15/26
摘要:
Derivatives of PSAs are synthesized, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.