Invention Grant
US08735586B2 Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
有权
苯并咪唑和氮杂苯并咪唑的区域选择性铜催化合成
- Patent Title: Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
- Patent Title (中): 苯并咪唑和氮杂苯并咪唑的区域选择性铜催化合成
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Application No.: US12644401Application Date: 2009-12-22
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Publication No.: US08735586B2Publication Date: 2014-05-27
- Inventor: Jorge Alonso , Andreas Lindenschmidt , Marc Nazaré , Matthias Urmann , Nis Halland , Omar Rkyek
- Applicant: Jorge Alonso , Andreas Lindenschmidt , Marc Nazaré , Matthias Urmann , Nis Halland , Omar Rkyek
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP07290800 20070626
- Main IPC: C07D235/08
- IPC: C07D235/08 ; C07D235/16 ; C07D235/18 ; C07D471/04
Abstract:
The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
Public/Granted literature
- US20100261909A1 Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles Public/Granted day:2010-10-14
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