发明授权
US08735604B2 Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
有权
吡咯烷作为胰高血糖素受体拮抗剂，组合物及其使用方法
- 专利标题： Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
- 专利标题（中）： 吡咯烷作为胰高血糖素受体拮抗剂，组合物及其使用方法
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申请号： US13496236申请日： 2010-09-16
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公开(公告)号： US08735604B2公开(公告)日： 2014-05-27
- 发明人: Eric J. Gilbert , Michael W. Miller , Duane Eugene DeMong , Andrew W. Stamford , William J. Greenlee
- 申请人： Eric J. Gilbert , Michael W. Miller , Duane Eugene DeMong , Andrew W. Stamford , William J. Greenlee
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Anna L. Cocuzzo; Catherine D. Fitch
- 国际申请： PCT/US2010/049088 WO 20100916
- 国际公布： WO2011/037815 WO 20110331
- 主分类号： C07D207/09
- IPC分类号： C07D207/09 ; A61K31/40
摘要：
The present invention relates to compounds of the general formula: (I) wherein ring B, R1, R2, R3, Z, and L1 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.