Invention Grant
- Patent Title: Multifunctional antibody conjugates
- Patent Title (中): 多功能抗体缀合物
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Application No.: US13305354Application Date: 2011-11-28
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Publication No.: US08741291B2Publication Date: 2014-06-03
- Inventor: Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
- Applicant: Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
- Applicant Address: IE Dun Laoghaire County, Dublin
- Assignee: Covx Technologies Ireland, Limited
- Current Assignee: Covx Technologies Ireland, Limited
- Current Assignee Address: IE Dun Laoghaire County, Dublin
- Agent Wendy L. Hsu
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.The invention further provides specific MAC compounds and compositions of the invention.
Public/Granted literature
- US20120201809A1 MULTIFUNCTIONAL ANTIBODY CONJUGATES Public/Granted day:2012-08-09
Information query
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