发明授权
US08741922B2 Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
有权
固体形式的N-（4-（7-氮杂双环[2.2,1]庚-7-基）-2-三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-甲酰胺
![Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide](/docs/US/2014-06-03/US08741922B2/abs.jpg.600x600.jpg)
- 专利标题： Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
- 专利标题（中）： 固体形式的N-（4-（7-氮杂双环[2.2,1]庚-7-基）-2-三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-甲酰胺
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申请号： US13751656申请日： 2013-01-28
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公开(公告)号： US08741922B2公开(公告)日： 2014-06-03
- 发明人: Beili Zhang , Mariusz Krawiec , Brian Luisi , Ales Medek
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理机构： Honigman Miller Schwartz and Cohn LLP
- 代理商 Christopher C. Forbes; Jonathan P. O'Brien
- 主分类号： A61K31/04
- IPC分类号： A61K31/04 ; A61K31/4748
![Solid forms of N-(4-(7-azabicyclo[2.2,1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide](/abs-image/US/2014/06/03/US08741922B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to substantially crystalline and solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (Form A-HCl, Form B, Form B-HCl, or any combination of these forms), pharmaceutical compositions thereof, and methods of treatment therewith.
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