A cancellation system is disclosed for processing incoming and outgoing signals in a transform domain to create a cancellation signal for reducing or removing unwanted interference. Data is ordered based on Good-Thomas indexing into a two dimensional array in a buffer. The two dimensional array may have lr rows and lw columns. From the buffer, the columns of data undergo a Winograd small transform. The rows of data undergo a Cooley-Tukey operation to complete the transform operation into the frequency domain. Multipliers scale the transformed data to generate a cancellation signal in the frequency domain. Inverse (Cooley-Tukey) and Winograd transforms perform inverse processing on the cancellation signal to return the cancellation signal or data to the time domain. Re-ordering the data and combination of the cancellation signal or data with incoming or outgoing signals achieve interference cancellation.