A device for drying medium flow (8), in particular an air flow, includes a device housing (2), in which at least first and second drying agents (4, 6) are received. The first and second drying agents have a high moisture absorption capacity in the case of low and high moisture values of the medium flow (8), respectively. The amount of the respective drying agent (4, 6) can be selectively set depending on the actual moisture present in the medium flow (8).