发明授权
US08747871B2 Synergistic matrix composite for making stable microemulsions of active ingredients
有权
用于制备稳定的微乳液活性成分的协同基质复合材料
- 专利标题: Synergistic matrix composite for making stable microemulsions of active ingredients
- 专利标题(中): 用于制备稳定的微乳液活性成分的协同基质复合材料
-
申请号: US11540981申请日: 2006-09-28
-
公开(公告)号: US08747871B2公开(公告)日: 2014-06-10
- 发明人: Kolazi S. Narayanan , Domingo Jon , Jayanti Patel , Karen Winkowski , Andreas Mitschke , Otto W. Gordon
- 申请人: Kolazi S. Narayanan , Domingo Jon , Jayanti Patel , Karen Winkowski , Andreas Mitschke , Otto W. Gordon
- 申请人地址: US DE Wilmington
- 专利权人: ISP Investments Inc.
- 当前专利权人: ISP Investments Inc.
- 当前专利权人地址: US DE Wilmington
- 代理机构: Thompson Hine LLP
- 代理商 William J. Davis
- 主分类号: A01N25/00
- IPC分类号: A01N25/00 ; A61K8/37
摘要:
What is described herein is a synergistic matrix composite for making a stable microemulsion in water of an active ingredient comprising a first matrix composition including by wt. (a) 5-30% of a C8-C18 N-alkyl pyrrolidone, (b) optionally, 5-60% of a water insoluble organic solvent soluble therein, (c) 30-70% of a non-ionic emulsifier, and (d) 1-15% of an EO/PO/EO copolymer, and, (e) optionally, 1-5% of a surface active buffering agent, e.g. a branched alkyl ethoxylated phosphate ester, a second matrix composition comprising a polar polymeric material, e.g. polyethylene glycol, and/or a neutralized derivatized vegetable oil, e.g. maleated linseed oil, which composite is capable of loading a higher amount of said active than either composition alone.
公开/授权文献
信息查询