Invention Grant
US08748100B2 Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
有权
用于选择性扩增，检测或定量具有特定末端序列的靶DNA的方法和试剂盒
- Patent Title: Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
- Patent Title (中): 用于选择性扩增，检测或定量具有特定末端序列的靶DNA的方法和试剂盒
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Application No.: US11897654Application Date: 2007-08-30
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Publication No.: US08748100B2Publication Date: 2014-06-10
- Inventor: Yuk Ming Dennis Lo , Yu Kwan Tong , Wai Kwun Rossa Chiu , Chunming Ding
- Applicant: Yuk Ming Dennis Lo , Yu Kwan Tong , Wai Kwun Rossa Chiu , Chunming Ding
- Applicant Address: CN Hong Kong
- Assignee: The Chinese University of Hong Kong
- Current Assignee: The Chinese University of Hong Kong
- Current Assignee Address: CN Hong Kong
- Agency: Seed IP Law Group, PLLC
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; C12N9/16
Abstract:
Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
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