发明授权
- 专利标题: Methods for treating glioma
- 专利标题(中): 治疗胶质瘤的方法
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申请号: US11791588申请日: 2005-10-27
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公开(公告)号: US08748445B2公开(公告)日: 2014-06-10
- 发明人: W. Joon Chung , Harald Sontheimer
- 申请人: W. Joon Chung , Harald Sontheimer
- 申请人地址: US AL Birmingham
- 专利权人: The UAB Research Foundation
- 当前专利权人: The UAB Research Foundation
- 当前专利权人地址: US AL Birmingham
- 代理机构: Bradley Arant Boult Cummings LLP
- 代理商 Thomas G. Peterson
- 国际申请: PCT/US2005/038380 WO 20051027
- 国际公布: WO2006/049957 WO 20060511
- 主分类号: A01N43/54
- IPC分类号: A01N43/54 ; A61K31/505 ; A01N43/40 ; A61K31/44 ; A01N41/10 ; A61K31/10 ; C07D239/02 ; C07D213/72 ; C07D211/72 ; C07D211/84 ; C07C315/00 ; C07C317/00
摘要:
The present disclosure provides for method of treatment and/or prevention of disease states that require cystine for maintenance or progression of the disease state. In addition, methods for screening and identifying novel therapeutic agents useful in the treatment of such disease states are described. In one embodiment, the disease state is a cancer, such as, but not limited to, glioma. In this embodiment, methods for the treatment and prevention of glioma by inhibiting cystine uptake or decreasing intracellular cystine concentrations are provided. The present disclosure teaches that glioma cells are dependent on system Xc for cystine uptake. Pharmacological inhibition of system Xc causes a rapid depletion of intracellular glutathione, resulting in decreased cell growth. In contrast, non-malignant astrocytes and cortical neurons remain viable in the presence of Xc inhibitors and continue to take up cystine via alternate amino acid transporters.
公开/授权文献
- US20090117031A1 Methods for Treating Glioma 公开/授权日:2009-05-07