发明授权
- 专利标题： Indolizine derivative and use thereof for medical purposes
- 专利标题（中）： 中和衍生物及其用途用于医疗目的
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申请号： US13259621申请日： 2010-03-30
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公开(公告)号： US08748452B2公开(公告)日： 2014-06-10
- 发明人: Kazuo Shimizu , Masato Iizuka , Yasushi Takigawa
- 申请人： Kazuo Shimizu , Masato Iizuka , Yasushi Takigawa
- 申请人地址： JP Matsumoto-shi
- 专利权人： Kissei Pharmaceutical Co., Ltd.
- 当前专利权人： Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Matsumoto-shi
- 代理机构： Westerman, Hattori, Daniels & Adrian, LLP
- 优先权： JP2009-086306 20090331; JP2009-279976 20091210
- 国际申请： PCT/JP2010/055692 WO 20100330
- 国际公布： WO2010/113942 WO 20101007
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61P13/12 ; A61P19/02 ; C07D471/04
摘要：
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. That is, the present invention relates to indolizine derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In the formula, ring U represents aryl or heteroaryl; R1 represents halogen, a hydroxy group or the like; R2 represents halogen, a hydroxy group, alkyl, alkoxy, alkyl substituted by fluorine, alkoxy substituted by fluorine or the like; m represents a number from 0 to 2; n represents a number from 0 to 3; and R3 represents hydrogen, fluorine or the like.
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