Invention Grant
US08748495B2 Method of preparing oil suspensions of carotenoid with low viscosity and high fluidity and use thereof
有权
制备低粘度和高流动性的类胡萝卜素油悬浮液的方法及其用途
- Patent Title: Method of preparing oil suspensions of carotenoid with low viscosity and high fluidity and use thereof
- Patent Title (中): 制备低粘度和高流动性的类胡萝卜素油悬浮液的方法及其用途
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Application No.: US13255271Application Date: 2010-03-04
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Publication No.: US08748495B2Publication Date: 2014-06-10
- Inventor: Xinde Xu , Guohua Wei , Xuebing Xiang , Bin Shao
- Applicant: Xinde Xu , Guohua Wei , Xuebing Xiang , Bin Shao
- Applicant Address: CN Zhejiang Province
- Assignee: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- Current Assignee: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- Current Assignee Address: CN Zhejiang Province
- Agency: Emerson Thomson Bennett, LLC
- Agent Daniel A. Thomson
- Priority: CN200910118952 20090309
- International Application: PCT/CN2010/000262 WO 20100304
- International Announcement: WO2010/102508 WO 20100916
- Main IPC: A61K31/122
- IPC: A61K31/122

Abstract:
The present invention relates to a method for preparing a carotenoid oil suspension with low viscosity and high fluidity. The method includes the steps of mixing carotenoid crystals with tetrahydrofuran, heating the resulting mixture to a reflux temperature of about 50˜70° C. under stirring, and filtering-the resulting solution to remove fat-soluble fibers. The resulting filtrate is then condensed to dryness, mixed with a ketone solvent, heated to a reflux temperature of about 60˜80° C., and filtered to remove non-soluble phospholipids. The filtrate obtained is condensed to a residue, and absolute alcohol is added to the residue, and then crystallized under stirring at room temperature. The resulting crystals are filtered and dried to-provide carotenoid crystals. The carotenoid crystals are ground and mixed with plant oils to provide a carotenoid oil suspension with low viscosity and high fluidity, which provides easy filling, for example, into capsules.
Public/Granted literature
- US20120329880A1 METHOD OF PREPARING OIL SUSPENSIONS OF CAROTENOID WITH LOW VISCOSITY AND HIGH FLUIDITY AND USE THEREOF Public/Granted day:2012-12-27
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