发明授权
US08754120B2 Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
有权
药物组合物包含罗替戈汀盐（酸或钠），特别是用于离子电渗疗法
- 专利标题： Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
- 专利标题（中）： 药物组合物包含罗替戈汀盐（酸或钠），特别是用于离子电渗疗法
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申请号： US13379333申请日： 2010-06-24
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公开(公告)号： US08754120B2公开(公告)日： 2014-06-17
- 发明人: Johanna Aaltje Bouwstra , Oliver Ackaert , Jacob Eikelenboom , Hans-Michael Wolff
- 申请人： Johanna Aaltje Bouwstra , Oliver Ackaert , Jacob Eikelenboom , Hans-Michael Wolff
- 申请人地址： DE Monheim
- 专利权人： UCB Pharma GmbH
- 当前专利权人： UCB Pharma GmbH
- 当前专利权人地址： DE Monheim
- 代理机构： Harness, Dickey & Pierce, P.L.C.
- 优先权： EP09008401 20090626
- 国际申请： PCT/EP2010/003796 WO 20100624
- 国际公布： WO2010/149363 WO 20101229
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; C07D333/20
摘要：
The present invention relates to new salts of 6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol (rotigotine), their use as a medicament, for example for the treatment of CNS disorders like Parkinson Disease, RLS, fybromyalgia and/or depression, in particular through electromotive administration. The present invention relates to pharmaceutical formulations suitable for iontophoresis that provide enhanced iontophoretic delivery of rotigotine to at least one target tissue. The formulations are further characterized by good to excellent solubility of the salts in aqueous solutions.
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