发明授权
US08759377B2 Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
有权
取代的二氧代哌啶和二氧代吡咯烷作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法
- 专利标题： Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
- 专利标题（中）： 取代的二氧代哌啶和二氧代吡咯烷作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法
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申请号： US12952640申请日： 2010-11-23
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公开(公告)号： US08759377B2公开(公告)日： 2014-06-24
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 代理机构： Stites & Harbison PLLC
- 代理商 Richard S. Myers, Jr.
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D401/12
摘要：
In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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