Invention Grant
US08759518B2 Intermediates for the preparation of HMG CoA reductase inhibitors and processes for the preparation thereof
失效
用于制备HMG CoA还原酶抑制剂的中间体及其制备方法
- Patent Title: Intermediates for the preparation of HMG CoA reductase inhibitors and processes for the preparation thereof
- Patent Title (中): 用于制备HMG CoA还原酶抑制剂的中间体及其制备方法
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Application No.: US13576296Application Date: 2011-02-23
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Publication No.: US08759518B2Publication Date: 2014-06-24
- Inventor: Shriprakash Dhar Dwivedi , Dhimant Jasubhai Patel , Mahesh Laljibhai Rupapara
- Applicant: Shriprakash Dhar Dwivedi , Dhimant Jasubhai Patel , Mahesh Laljibhai Rupapara
- Applicant Address: IN Ahmedabad
- Assignee: Cadila Healthcare Limited
- Current Assignee: Cadila Healthcare Limited
- Current Assignee Address: IN Ahmedabad
- Agency: Ladas & Parry LLP
- Priority: IN481/MUM/2010 20100223; IN1820/MUM2010 20100617
- International Application: PCT/IN2011/000108 WO 20110223
- International Announcement: WO2011/104725 WO 20110901
- Main IPC: C07D239/02
- IPC: C07D239/02 ; C07D405/12 ; C07D239/42 ; C07D405/06 ; C07D257/04

Abstract:
A compound of Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R4a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF3, halo and NO2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.
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