- 专利标题： Cytotoxic benzodiazepine derivatives
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申请号： US13397195申请日： 2012-02-15
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公开(公告)号： US08765740B2公开(公告)日： 2014-07-01
- 发明人: Wei Li , Michael Miller , Nathan Fishkin , Ravi V. J. Chari
- 申请人： Wei Li , Michael Miller , Nathan Fishkin , Ravi V. J. Chari
- 申请人地址： US MA Waltham
- 专利权人： ImmunoGen, Inc.
- 当前专利权人： ImmunoGen, Inc.
- 当前专利权人地址： US MA Waltham
- 代理机构： McCarter & English, LLP
- 代理商 Steven G. Davis; Yu Lu
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; A61K31/5517 ; A61K31/55 ; A61P35/00
摘要：
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
公开/授权文献
- US20120244171A1 CYTOTOXIC BENZODIAZEPINE DERIVATIVES 公开/授权日：2012-09-27
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