Methods, apparatuses and storage medium associated with ISA bridging with support for virtual functions, are disclosed. In embodiments, at least one computer-readable storage medium may include instructions configured to enable a target device with a target ISA, in response to execution, to provide an ISA bridging layer to the target device to facilitate a library service of a library of the target device to call a virtual function of the library, while servicing an application operating on the target device, where the application has an overriding implementation. The ISA bridging layer may include a loader configured to load the application for execution, and as part of loading the application, detect the virtual function and modify a virtual function table of the application to enable the call. Other embodiments may be disclosed or claimed.