The invention provides a multi-piece solid golf ball having a core, an envelope layer which encloses the core, an intermediate layer which encloses the envelope layer, and a cover which encloses the intermediate layer and has formed on a surface thereof a plurality of dimples. The core is formed primarily of a rubber material, the envelope layer is formed primarily of a specific resin mixture, the intermediate layer is formed primarily of a resin material, and the cover is formed primarily of polyurethane. The intermediate layer and the cover have surface hardnesses (Durometer D hardness) which satisfy the relationship: intermediate layer surface hardness>cover surface hardness. The golf ball has an excellent flight performance and controllability that are acceptable to professionals and other skilled golfers, while also having an excellent durability to cracking on repeated impact and an excellent scuff resistance.