发明授权
US08772504B2 Substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators
有权
取代的苯并恶唑，苯并咪唑，恶唑并吡啶和咪唑并吡啶衍生物作为γ分泌酶调节剂
- 专利标题： Substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators
- 专利标题（中）： 取代的苯并恶唑，苯并咪唑，恶唑并吡啶和咪唑并吡啶衍生物作为γ分泌酶调节剂
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申请号： US13144557申请日： 2010-02-15
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公开(公告)号： US08772504B2公开(公告)日： 2014-07-08
- 发明人: Henricus Jacobus Maria Gijsen , François Paul Bischoff , Wei Zhuang , Sven Franciscus Anna Van Brandt , Michel Surkyn , Mirko Zaja , Didier Jean-Claude Berthelot , Michel Anna Jozef De Cleyn , Gregor James MacDonald , Daniel Oehlrich
- 申请人： Henricus Jacobus Maria Gijsen , François Paul Bischoff , Wei Zhuang , Sven Franciscus Anna Van Brandt , Michel Surkyn , Mirko Zaja , Didier Jean-Claude Berthelot , Michel Anna Jozef De Cleyn , Gregor James MacDonald , Daniel Oehlrich
- 申请人地址： US NJ Titusville GB Brentford, Middlesex
- 专利权人： Janssen Pharmaceuticals, Inc.,Cellzome Limited
- 当前专利权人： Janssen Pharmaceuticals, Inc.,Cellzome Limited
- 当前专利权人地址： US NJ Titusville GB Brentford, Middlesex
- 代理机构： Baker & Hostetler LLP
- 优先权： EP09153188 20090219; EP09163409 20090622
- 国际申请： PCT/EP2010/051843 WO 20100215
- 国际公布： WO2010/094647 WO 20100826
- 主分类号： C07D235/00
- IPC分类号： C07D235/00 ; C07D403/02
摘要：
The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.