A method of manufacturing a wire for straightening irregular teeth, which is not harmful to a human body and preserves the color of the teeth, is provided. The method of manufacturing a wire for straightening irregular teeth includes manufacturing a metal wire with metal alloy; physically or chemically etching a surface of the metal wire and then performing heat treatment; coating the surface of the metal wire with a metal material, Teflon, epoxy or urethane to show white or ivory and then performing heat treatment; forming a transparent parylene film on the metal material, Teflon, epoxy or urethane and then performing heat treatment; and removing one side of the foregoing coating layer from the surface of the metal wire, and then applying surface treatment to the one side with the coating layer removed.