发明授权
US08778967B2 Chemokine receptor binding heterocyclic compounds with enhanced efficacy
有权
趋化因子受体结合杂环化合物具有增强的疗效
- 专利标题： Chemokine receptor binding heterocyclic compounds with enhanced efficacy
- 专利标题（中）： 趋化因子受体结合杂环化合物具有增强的疗效
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申请号： US13358041申请日： 2012-01-25
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公开(公告)号： US08778967B2公开(公告)日： 2014-07-15
- 发明人: Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri
- 申请人： Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri
- 申请人地址： US MA Cambridge
- 专利权人： Genzyme Corporation
- 当前专利权人： Genzyme Corporation
- 当前专利权人地址： US MA Cambridge
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; C07D403/12
摘要：
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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